Project Report

“Evaluation of anti-diabetic and anti-inflammatory activity of selective phytoconstituents from Hyptis suaveolens (L.) Poit: an in silico molecular docking and ADMET study

2025-10-16T21:01:59Z

“Evaluation of anti-diabetic and anti-inflammatory activity of selective phytoconstituents from Hyptis suaveolens (L.) Poit: an in silico molecular docking and ADMET study Islam, Mohammed Murshedul The use of medicinal plants to treat DM and Inflammation is popular, as herbal drugs are generally regarded as free of toxic effects. Moreover, the limitations of oral anti-diabetic and anti-inflammatory drugs urge to find new drugs for treatment of DM and inflammation. Therefore, the search for more effective and safer herbal hypoglycemic agents, anti-inflammatory agents and developing new anti-diabetic drugs, anti-inflammatory drugs with improved clinical profiles simultaneously have become an area of active research. Numerous animal studies have shown positive anti-inflammatory and antioxidant capabilities of several physiologically active compounds present in plant extracts. It is yet unclear how these substances, which are found in phytochemical extracts, interact molecularly with the target proteins or enzymes that provide antioxidant and anti-inflammatory properties.. Project

Survey on Anal Fistula in Dhaka Medical College Hospital, Dhaka.

2025-10-16T21:01:16Z

Survey on Anal Fistula in Dhaka Medical College Hospital, Dhaka. Rabbi, Mehedi Hasan Anal fistula is a common condition where abnormal passages form between the anal canal and surrounding tissue. Infection, especially abscess formation, is a major cause of this condition. Traditional treatments like fistulotomy or fistulectomy are effective but can result in fecal incontinence if the muscles are involved. To prevent incontinence, sphincter-preserving techniques like Seton drainage, fibrin sealant closure, and ligation of the intersphincteric fistula tract (LIFT) have been suggested. However, these methods have different success rates and may require multiple surgeries. Recurrent anal fistulas are even more challenging and are often associated with a higher risk of recurrence and fecal incontinence. It is important to use imaging techniques like endoanal ultrasonography and MRI to thoroughly assess the condition and plan treatment. While conventional surgical options are still common, newer techniques like LIFT and anal fistula plugs aim to minimize damage to the sphincter and preserve function. Despite promising results, there are still challenges to overcome, particularly when it comes to long-term effectiveness and recurrence rates. However, a comprehensive understanding of fistula anatomy and treatment options is essential for improving patient outcomes and reducing treatment failures. This survey aims to clarify the causes, prevalence, and treatment options for anal fistula. Additionally, it aims to improve knowledge of potential postoperative issues after anal fistula surgeries and offers solutions Project

Phytochemical profiling, and neuroendocrine studies of methanolic extract of Malva parviflora in experimental wester albino mice

2025-10-16T21:01:15Z

Phytochemical profiling, and neuroendocrine studies of methanolic extract of Malva parviflora in experimental wester albino mice Rizon, Abdullah All In everyday life, we have to deal with stress, sadness, and depression which is very common in that time. Neurodisorders disrupt our personal and social life. The purpose of this research was to investigate the neuro-pharmacological characteristics of Malva parviflora leaves. CNS activity were investigated through hole cross, hole board and open field tests at varied extract dosages(50 & 125mg) per kg body weight, also aims to examine how Malva parviflora, a plant, may reduce stress levels by measuring blood glucose and serum cortisol levels. And To determine the impact of antidepressant medications on blood glucose and serum cortisol levels in experimental mice . In case of CNS depressant activity significantly reduction of frequent locomotor and exploratory activity was found in hole cross (P< 0.001) and open field test P < 0.05, P < 0.01, P < 0.001. Furthermore, both extracts also decreased the significant numbers (P < 0.001) of head dips by mice in hole-board test. On the other hand, Blood was collected by a cardiac puncture, and glucose and cortisol levels were measured using a spectrophotometer. The blood glucose level for herbal sample (chemical induction) were respectively 4.75 ±0.27 for high dose and low dose 3.76± 0.41 in compare to control were 4.83±0.88 mmol/L. It was 5.16±0.88 for standard groups. Secondly for Heat Induction The blood glucose level for herbal sample were respectively 4.85±0.37 for high dose and low dose 5.43± 0.04 comparing with control group which was 10.91±1.32 mmol/L. Where standard was 4.59±0.88 . For Serum cortisol level in Chemical Induced test 2.78± 0.10 & 1.51± 0.21 ug/dl for two plant extract and in standard group drug that was 1.32± 0.17 ug/dl & for control group it was 2.30± 0.11 and in heat induction, for control it was3.32± 0.54, for standard 1.47± 0.34 and lastly in terms of sample 200mg level was 2.97± 0.11 and for sample 400mg 2.12± 0.54 . According to this research, herbal plant have ability to reduce stress within a normal range, although further research is required to substantiate this claim Project

Therapeutic Potential of Centella asiatica (Gotu Kola) in Mental Health: A Review of its Cognitive Enhancing and Anxiolytic Effects

2025-10-16T21:01:07Z

Therapeutic Potential of Centella asiatica (Gotu Kola) in Mental Health: A Review of its Cognitive Enhancing and Anxiolytic Effects Tanvir, Md. Shakib Hossan Mental health disorders, including cognitive impairment and anxiety disorders, pose significant challenges to global public health. Despite advancements in pharmacotherapy and psychotherapy, the quest for safe and efficacious treatment options remains ongoing. This comprehensive review explores the therapeutic potential of Centella asiatica (Gotu Kola) in mental health, synthesizing evidence from preclinical and clinical studies. Preclinical investigations have demonstrated Centella asiatica's ability to enhance cognitive function, mitigate anxiety and depression-like behaviors, and exert neuroprotective effects in various animal models. Clinical trials support these findings, showing significant improvements in cognitive function, anxiety, and depression symptoms among human participants. For instance, cognitive function improvement was observed in 75% of healthy adults following Centella asiatica supplementation, while reductions in anxiety symptoms were reported in 60% of patients receiving treatment. Moreover, approximately 70% of patients experienced a reduction in depressive symptoms with Centella asiatica supplementation. The herb's mechanisms of action involve modulation of neurotransmitter systems, neurogenesis promotion, and antioxidant properties. Additionally, Centella asiatica demonstrates stress management benefits and antiaging properties, further enhancing its therapeutic potential in mental health care. Integration of traditional knowledge with modern scientific methodologies facilitates a holistic understanding of Centella asiatica's therapeutic effects and cultural significance. Sustainable cultivation practices and formulation considerations are crucial for optimizing therapeutic outcomes and ensuring the availability of high-quality Centella asiatica. Overall, Centella asiatica emerges as a promising botanical remedy for enhancing cognitive function, alleviating anxiety and depression symptoms, and promoting mental well-being. Further research is warranted to elucidate its mechanisms of action, optimize treatment regimens, and explore its clinical applications in mental health care. Project