Project Reporthttp://dspace.daffodilvarsity.edu.bd:8080/handle/123456789/13502024-03-29T08:02:07Z2024-03-29T08:02:07ZScientific exploration of Cytotoxic, Anti-Oxidant and Thrombolytic Activity of methanolic extract of Cassia Fistula (Leaves) and Cicer arietinum (Fruits) RemediesUddin, Mohammad Borhanhttp://dspace.daffodilvarsity.edu.bd:8080/handle/123456789/118502024-03-25T21:00:44Z2024-01-20T00:00:00ZScientific exploration of Cytotoxic, Anti-Oxidant and Thrombolytic Activity of methanolic extract of Cassia Fistula (Leaves) and Cicer arietinum (Fruits) Remedies
Uddin, Mohammad Borhan
The investigation looked into the scientific underpinnings of the plants' potential
medical uses, including their cytotoxic, thrombolytic, and antioxidant properties. Both
the chickpea remedy and the Cassia fistula remedy showed moderate cytotoxic and
notable thrombolytic and antioxidant activities, according to the study, indicating that
they might be utilized as possible natural medication sources for the treatment of a
range of illnesses.
Objectives: To assess the possible chemical components and assess the effects on
thrombolysis, antioxidants, and cytotoxicity.
Materials & Methods: Methanol was used to extract the plant material from Cassia
fistula and Cicer arietinum for the phytochemical testing, which were conducted in a
lab. The thrombolytic test was conducted, and the coat lysis method was used to carry
out the thrombolytic activity. The Brine Shrimp method was used to measure cytotoxic
activity, while the free radical scavenging method was used to screen for antioxidants.
Results: Numerous chemical components, including alkaloids, carbohydrates,
tannins, glycosides, and saponins, were found in the extract of Cassia fistula and
Cicer arietinum, according to phytochemical study. When the output of thrombolytic
activity from these plant remedies is compared to the usual value of streptokinase
(75.29%, Previous report), it is 39.35%. Additionally displayed is the antioxidant
activity (IC50=5.56), which is contrasted with the standard ascorbic acid
(IC50=9.072). The methanolic extract of Cassia fistula exhibits cytotoxic effect
because its LC50 value is almost the same as that of vincristine sulfate.
Conclusion: The plant exhibits phytochemical and pharmacological activities
(thrombolytic, antioxidant, and cytotoxic) according to the data gathered.
2024-01-20T00:00:00ZPrevalence and Risk Factors of Polycystic Ovarian Syndrome Among WomenNasrin, Atiahttp://dspace.daffodilvarsity.edu.bd:8080/handle/123456789/118492024-03-25T21:00:34Z2024-01-20T00:00:00ZPrevalence and Risk Factors of Polycystic Ovarian Syndrome Among Women
Nasrin, Atia
The illness known as polycystic ovarian syndrome, or PCOS, is diverse and
mainly unidentified. The most commonly used diagnostic criteria for PCOS are
the Rotterdam criteria, which are defined by polycystic ovaries,
oligo/anovulation, and physical or biochemical evidence of hyperandrogenism.
A diagnosis of PCOS and all associated consequences will be given for any two
of the three, after other possible complicating conditions have been ruled out.
Given the increased risk of infertility, cardiovascular disease, type 2 diabetes,
and gynecologic malignancies associated with a PCOS diagnosis, it is critical
that the right diagnosis be established and that screening protocols be followed.
Every PCOS consequence has a variety of treatments available, ranging from in
vitro fertilization to lifestyle changes. These are going to be discussed in the
next.
2024-01-20T00:00:00ZEvaluation of anti-diabetic and anti-inflammatory activity of selective phytoconstituents from Hyptis suaveolens (L.) Poit: an in silico molecular docking and ADMET studyIslam, Mohammed Murshedulhttp://dspace.daffodilvarsity.edu.bd:8080/handle/123456789/115662024-02-29T21:00:49Z2024-01-13T00:00:00ZEvaluation of anti-diabetic and anti-inflammatory activity of selective phytoconstituents from Hyptis suaveolens (L.) Poit: an in silico molecular docking and ADMET study
Islam, Mohammed Murshedul
The use of medicinal plants to treat DM and Inflammation is popular, as herbal drugs are generally
regarded as free of toxic effects. Moreover, the limitations of oral anti-diabetic and anti-inflammatory drugs
urge to find new drugs for treatment of DM and inflammation. Therefore, the search for more effective
and safer herbal hypoglycemic agents, anti-inflammatory agents and developing new anti-diabetic drugs,
anti-inflammatory drugs with improved clinical profiles simultaneously have become an area of active
research. Numerous animal studies have shown positive anti-inflammatory and antioxidant capabilities of
several physiologically active compounds present in plant extracts. It is yet unclear how these substances,
which are found in phytochemical extracts, interact molecularly with the target proteins or enzymes that
provide antioxidant and anti-inflammatory properties.
The current effort attempts to identify and evaluate putative biological targets as proteins or enzymes
involved in these targeted studies using molecular docking as a computational approach. To extract a
variety of phytochemicals from Hyptis suaveolens (L.) Poit, the curated database IMPPAT: Indian
Medicinal Plants, Photochemistry and Therapeutics has been used. These phytochemicals are further
evaluated by molecular docking against two proteins (4EMA and 1PXX) associated with antioxidant and
antidiabetic properties. Beta-sitosterol, ovatodiolide, neoabietinol, apigenin, dehydroabietinol,
cyclooxygenase-2 (COX-2) (PDB: 1PXX), and peroxisome proliferator-activated receptor gamma (PPARĪ³) (PDB ID: 4EMA) are a few phytochemicals that have shown encouraging binding affinities towards
target proteins.
To determine the pharmacokinetic and pharmacodynamic properties of these compounds as possible
therapeutic agents against inflammatory and antidiabetic disorders, employing ADMET prediction and in
silico docking studies of specific phytoconstituents. Molecular docking was also utilized to confirm these.
Based on their binding affinities and docking scores, many phytochemicals (Beta-Sitosterol, Ovatodiolide,
Neoabietinol, Apigenin, Dehydroabietinol, and Spathulenol) were demonstrated to be able to bind protein
targets (4EMA, 1PXX). More in vitro research is needed to fully understand the target-based antiinflammatory and anti-diabetic effects of these newly identified phytochemicals.
2024-01-13T00:00:00ZReview and Analysis of Knowledge About Self-Medication Among Rural People in BangladeshKhatun, Rupahttp://dspace.daffodilvarsity.edu.bd:8080/handle/123456789/110732023-08-27T21:00:51Z0023-07-30T00:00:00ZReview and Analysis of Knowledge About Self-Medication Among Rural People in Bangladesh
Khatun, Rupa
Background: Self-medication, the practice of treating minor health issues without consulting healthcare professionals, is common among rural populations in Bangladesh. Understanding the patterns and factors associated with self-medication is essential for developing targeted interventions and promoting safe healthcare practices.
Methods: A survey was conducted among rural people in Bangladesh to gather information about self-medication practices. The survey questionnaire included questions about the participants' gender, age, occupation, education level, self-medication practices, reasons for self-medication, sources of medication information, awareness of risks, and perception of healthcare availability. A total of 200 participants were surveyed, and the data was analyzed to identify patterns and trends. The survey was conducted during the period from May 3, 2023 to June 3, 2023.
Results: The survey revealed that self-medication is prevalent among rural individuals, with 77.5% of participants engaging in self-treatment for minor health issues. Headache (65%), fever (55%), and cough/cold symptoms (47.5%) were the most common health issues for which self-medication was practiced. Painkillers (70%) and cough and cold medicines (45%) were the most commonly used medications. Healthcare professionals (45%), family and friends (32.5%), and online sources (30%) were the main sources of medication information. The primary reasons for self-medication were the cost of healthcare services (60%) and lack of nearby healthcare facilities (35%). While 55% of participants were aware of the potential risks associated with self-medication, 15% had partial awareness, and 30% had no awareness. The perceived availability of healthcare services was rated as excellent (7.5%), good (30%), fair (47.5%), and poor (15%).
Conclusion: Self-medication is prevalent among rural people in Bangladesh, influenced by cost, healthcare accessibility, and medication availability. Targeted education and interventions are needed to promote responsible self-medication practices. Enhancing healthcare accessibility and increasing awareness of self-medication risks are crucial. Policymakers and healthcare providers must take action to ensure safe and informed self-medication practices among rural populations in Bangladesh.
0023-07-30T00:00:00Z