http://dspace.daffodilvarsity.edu.bd:8080/handle/123456789/14417 2026-04-04T22:13:18Z http://dspace.daffodilvarsity.edu.bd:8080/handle/123456789/15054 Phytochemical Screening and Biological Tests of Methanol Extract of Ruellia simplex Tasnim, Mst. Saima The phytochemical composition and possible biological activities of Ruellia simplex, a medicinal herb that has conventional uses, were studied. Plant material was extracted using methanol, and the resultant extract was thoroughly screened for the existence of several secondary metabolites using phytochemical analysis. Alkaloids, flavonoids, Saponin, Glycoside, and tannins were found in the results of the research, indicating the plant’s varied chemical composition. The biochemical properties of the Ruellia simplex methanol extract were then assessed using a battery of in vitro experiments and in-vivo anti-diarrheal, in-vitro thrombolytic activity, in vitro antioxidant & in vivo anthelminthic activity. Ruellia Simplex methanol extract showed adequate thrombolytic effectiveness (69%), according to this investigation. Standard ascorbic acid’s DPPH inhibitory effect displays the IC50 (9.072 μg/ml) as the positive control. The Methanol extract of Ruellia Simplex has a notable DPPH inhibitory effect, with an IC50 of 20.487 μg/ml when compared to standard. The findings of this research emphasize Ruellia simplex’s potential uses in medicine and healthcare by providing significant details on the phytochemical makeup of the plant and its biological activities. The results highlight the significance of looking for novel therapeutic compounds in natural sources and may open the door for future studies Thesis 2024-01-22T00:00:00Z http://dspace.daffodilvarsity.edu.bd:8080/handle/123456789/15053 A Novel Analytical Method Development of Esomeprazole Pellet Sarker, Md. Shah Newaj Proton pump inhibitors (PPIs), also called gastric medicine, are among the most frequently prescribed medications globally. Medications such as Esomeprazole, Omeprazole, Pantoprazole, and others have nearly become ubiquitous in Bangladesh. Although available in various forms on the market, capsules (pellets) are the most prevalent. Analyzing pharmaceuticals is laborious because only a limited number of pharmaceutical companies produce them internally; the rest purchase granules that have been filled into capsule shells and sold. Thus, only a few in-house methods exist to facilitate the analytical process. The majority of them rely on pharmacopoeial methods such as BP and USP. Although these techniques are widely used, they may only apply to some pharmaceuticals. Therefore, this study is preoccupied with developing a novel technique to facilitate the analysis of PPI pellets. It is a finished product for a company that has only sold granules; it is a raw material for a purchaser. The analytical technique can, therefore, be identical for both. For an analyst to analyze these PPI granules, an effective method for both the primary material and the final product must exist. This analysis uses High-Performance Liquid Chromatography (HPLC), the most effective method for separating and identifying mixtures of various components. In addition, distinct reagent and chromatographic conditions are implemented, given that this is a novel methodology. The ultimate findings exhibit encouraging results. This approach reduces both time and analysis costs, albeit with minor drawbacks. Esomeprazole, PPI, particle analysis, HPLC, and the development of analytical methods are all keywords Thesis 2024-01-22T00:00:00Z http://dspace.daffodilvarsity.edu.bd:8080/handle/123456789/15052 A survey on Knowledge, Attitude, and Practice towards taking Proton Pump Inhibitors (PPIs) among Bangladeshi villagers Sarker, Mithun It is a survey on Knowledge, Attitude, and Practice towards taking Proton Pump Inhibitors (PPIs) among Bangladeshi villagers. Out most of the villagers don’t know about proper use of PPIs. They do not know when it will be taken and why the are taken PPIs? There haven’t any awareness between most of the Bangladeshi villagers. Who don’t have any formal educational knowledge the take PPIs without doctor’s advice. They go to pharmacy and bye PPIs. They don’t know about dose of the PPIs at a time. The take their own advice. They take it after taking food. That’s why it can not work properly. In the result Most of the Bangladeshi villagers are use PPIs. Most of them are woman and who do not have any educational knowledge the use without doctors prescription. Who are Educated they know everything about PPIs. But one part of educated villagers don’t know when it will be take. They take it after taking food. That’s why it can’t work 100% or properly. They do not know about it’s demerits. They don’t have any knowledge it create some adverse effect after taking PPIs. On the other hand who are un educated, don’t have any academic knowledge they don’t have any knowledge about PPIs. They take it without doctor’s prescription. They do not know when it will be taken. And they take it randomly. They also don’t know 30-60 minutes before taking food it will be taken. That’s why there are suffering mane problems and for that reasons PPIs can not work properly. For that reason PPIs don’t it’s 100%. Thesis 2024-01-22T00:00:00Z http://dspace.daffodilvarsity.edu.bd:8080/handle/123456789/15051 "Phytochemical screening & antistress activities of the methanolic extracts of Melochia Corchorifolia leaves Bappy, Rakiba Akter The present study was undertaken to evaluate the possible “phytochemical screening and antistress activities of the methanol extracts of Melochia Corchorifolia leaves” (family: Sterculiaceae. The leaf's methanol and water extracts have been shown in numerous studies to have antibacterial, antifungal, cytotoxic, and anti-cancer properties. Using conventional procedures, the methanolic extract underwent a phytochemical examination. Numerous phytoconstituents were found, including glycosides, terpenoids, alkaloids, steroids, tannins, phenols, and saponins, according to the analysis. The design research investigates the impacts of spleen anatomy, blood glucose levels, weight fluctuation, and anti stress exercise. The stress group had blood glucose levels of 10.23 ± 1.08 mmol/L and 7.43 ± 0.89 mmol/L, whereas the medicinal sample group had values of 8.9 ± 0.81 mmol/L and 11.03 ± 0.37 mmol/L, respectively. The stress group had a cortisol level of 4.17± 0.19 ug/dl, whereas the medicinal sample group and standard group had levels of 2.13± 0.30 ug/dl and 3.17± 0.18 ug/dl, respectively. Weight fluctuation for the stress group was 26.66 ± 1.20gm, whereas the sample group was 25 ±1 gm. A morphological analysis of the spleen was done in order to evaluate and compare the effectiveness of conventional and herbal medicines against the spleen mass. Thesis 2024-01-01T00:00:00Z