Faculty of Health and Life Sciences
http://dspace.daffodilvarsity.edu.bd:8080/handle/123456789/18
2024-03-29T10:12:33ZPhytochemical screening and anti stress activities of the methanolic extracts of Melochia Corchorofolia leaves.
http://dspace.daffodilvarsity.edu.bd:8080/handle/123456789/11899
Phytochemical screening and anti stress activities of the methanolic extracts of Melochia Corchorofolia leaves.
Bappy, Rakiba Akter
The present study was undertaken to evaluate the possible “phytochemical screening
and antistress activities of the methanol extracts of Melochia Corchorifolia leaves”
(family: Sterculiaceae. The leaf's methanol and water extracts have been shown in
numerous studies to have antibacterial, antifungal, cytotoxic, and anti-cancer
properties. Using conventional procedures, the methanolic extract underwent a
phytochemical examination. Numerous phytoconstituents were found, including
glycosides, terpenoids, alkaloids, steroids, tannins, phenols, and saponins, according
to the analysis. The design research investigates the impacts of spleen anatomy, blood
glucose levels, weight fluctuation, and anti stress exercise. The stress group had
blood glucose levels of 10.23 ± 1.08 mmol/L and 7.43 ±
0.89 mmol/L, whereas the medicinal sample group had values of 8.9 ± 0.81 mmol/L and
11.03 ±
0.37 mmol/L, respectively. The stress group had a cortisol level of 4.17± 0.19 ug/dl,
whereas the medicinal sample group and standard group had levels of 2.13± 0.30 ug/dl
and 3.17± 0.18 ug/dl, respectively. Weight fluctuation for the stress group was 26.66 ±
1.20gm, whereas the sample group was 25 ±1 gm. A morphological analysis of the
spleen was done in order to evaluate and
compare the effectiveness of conventional and herbal medicines against the spleen mass.
2024-01-23T00:00:00ZIn silico and in vitro antimicrobial evaluation of methanol extract of Artocarpus heterophyllus leaves against gram-positive and gram-negative bacteria
http://dspace.daffodilvarsity.edu.bd:8080/handle/123456789/11887
In silico and in vitro antimicrobial evaluation of methanol extract of Artocarpus heterophyllus leaves against gram-positive and gram-negative bacteria
Islam, Md. Rezaul
Antibiotic resistance threatens global health, necessitating a search for new antibiotic drugs.
Artocarpus heterophyllus has therapeutic potential in many cultures. The purpose of this study
evaluation of antimicrobial activities of leaf compounds based on in silico and in vitro
approaches. The study evaluated the phytochemical screening test of Artocarpus heterophyllus
leaves, focusing on its antibacterial activity against gram-positive and gram-negative bacteria
through in vitro and silico analysis. The antibacterial activity was assessed in the laboratory
where Ciprofloxacin was used as the standard. We used computational tools to predict the
interaction between bioactive compounds and major bacterial proteins Peptidoglycan
glycosyltransferase, involving molecular docking studies. We selected 10 compounds from a
literature review and analyzed their PASS prediction data for further confirmation. The zone of
inhibition on gram-positive and gram-negative bacteria was determined by the disk diffusion
method using two concentration samples, with maximum diameters of 11mm and minimum
diameters of 6mm for 250μg/disc and 15mm for 10mm for 500μg/disc. The binding affinity was
determined through molecular docking, while the stability analysis and calculation were
performed using the Quantitative Structure-Activity Relationship (QSAR) study. The molecular
weight and bioavailability of a drug were determined through analysis of pharmacokinetics data
and the Lipinski Rule. Ligands 01, 05, and 07 contain low molecular weight and the highest
binding affinity to bacterial protein Peptidoglycan glycosyltransferase. In the same way, these
ligands have more stability and no hepatotoxicity. These results provide a new opportunity for
the advancement of pharmaceutical research and further experimental studies need to be
performed on the Artocarpus heterophyllus leaf compounds and Peptidoglycan
glycosyltransferase.
2024-01-15T00:00:00ZA Survey Study on Knowledge and Awareness about Monkeypox Among the People of Dhaka, Bangladesh.
http://dspace.daffodilvarsity.edu.bd:8080/handle/123456789/11886
A Survey Study on Knowledge and Awareness about Monkeypox Among the People of Dhaka, Bangladesh.
Hossain, Rajib
Human monkeypox is a zoonotic Orthopoxvirus with a presentation similar to smallpox.
Monkeypox that started spreading from central and western Africa has recently been detected in
various countries including Spain, Canada, Australia, and UAE. Despite its rare occurrence, it
remains a substantial danger that necessitates prompt action, and the likelihood of it disseminating
to numerous other nations is still considerable. Bangladesh has not reported any cases of
monkeypox so far, but to prevent the spread of the virus that has affected many parts of the world,
the country has issued a health notice. Our nearby country India reported ten confirmed instances
of the disease on December 8, 2022, with one case each in Delhi and Telangana, and four cases
each in Bihar and Uttar Pradesh. So, knowledge and awareness required for prevention of
monkeypox.
The objective of this study to gather knowledge and awareness about monkeypox among
Bangladeshi people. This study also find concern about vaccination and death rate of Monkeypox.
In my survey among the respondents, 111(85.7%) respondents know about monkeypox and
23(12.6%) respondents have no idea about monkeypox. Respondents know about the common
sign and symptoms of Monkeypox. Among the respondents, 111(86.3%) responded fever,
95(81.2%) responded headache, 57(48.7%) responded muscle aches, 44(37.6%) responded back
pain, 44(37.6%) responded low energy, 44(37.6%) responded swollen lymph nodes, 84(71.8%)
responded rash, 19(16.2%) responded others are the common symptoms of Monkeypox.
Respondents also know about how it spread from human to human. 81(69.8%) responded it is
spread by touching contaminated objects, 74(63.8%) responded its spread by air, 63(53.5%)
responded it spread by close contact of infected person. They also show positive response about
how it spread from animals to human. Among the respondents 102(87.9%) responded it spread by
contact with infected animals, 62(53.4%) responded it spread by eating unwell cooked meat,
61(50.9%) responded it spread through bites of infected animals. Respondents also concern about
the awareness will take for protect them self and others against Monkeypox. 98(84.5%)
respondedavoiding unprotected contact with wild animals, 80(69%) responded protect by social
awareness, 65(56%) responded by wearing mask, 59(50.9%) responded protect by clean hand
frequently, 56(48.3%) thought protect by isolation. Respondent also knows about the vaccine.
37(32.2%) strongly agreed that, smallpox vaccine are highly effective against monkeypox,
38(33%) responded neutral about it, 10(8.7%) disagreed about it smallpox vaccine are not
effective against Monkeypox.
2024-01-15T00:00:00ZA survey on the knowledge and perceptions of long term uses of proton pump inhibitors among patients with gastrointestinal disorders in Dhaka medical college hospital
http://dspace.daffodilvarsity.edu.bd:8080/handle/123456789/11885
A survey on the knowledge and perceptions of long term uses of proton pump inhibitors among patients with gastrointestinal disorders in Dhaka medical college hospital
Shanta, Sanzida Sharmin
Proton pump inhibitors (PPIs) are widely prescribed medications for the management of
various gastrointestinal disorders. This survey aims to investigate the knowledge and
perceptions of patients with gastrointestinal disorders regarding the extended use of PPIs.
The study employs a cross-sectional design, utilizing a structured questionnaire
administered to a diverse sample of patients diagnosed with gastrointestinal disorders who
are currently undergoing long-term PPI therapy. The survey assesses participants'
awareness of the indications for PPI use, understanding of potential side effects and risks
associated with prolonged usage, and their perceptions of the necessity for continued
medication. In this investigation most of the responders (77%) have been affected
gastrointestinal disease. Majority of the responders 44% replied they have been diagnosed
gastrointestinal disease from less than one year, 31% responders replied they have been
diagnosed gastrointestinal disease from 1-5 years. Among them majority participants 30%
responded that they have been suffered Gastroesophageal reflux disease (GERD). Also
20% participant’s responded that they have been suffered change in normal bowel habits.
According to the survey, most of the responders (78%) have been said they haven’t aware
about complication of long term use of Proton Pump Inhibitor (PPI). 32% participants
replied that they have been suffered Bone fractures, 25% responded suffered Clostridium
difficile-associated diarrhea, and 18% replied they suffered chronic kidney disease due to
long term use of Proton Pump Inhibitor (PPI). In this investigation, maximum participants
55% replied that they have been taken PPI daily, 22% replied 2-3 times a week and 18%
replied 4-5 times a week taken Proton Pump Inhibitor. Majority of the participants 92%
replied that they have been taken regularly PPI without doctor prescribing. Here
demonstrate that 40% responders replied they have been PPI in morning empty stomach,
25% replied they have been taken PPI at night 30 min before and 30% responders taken
after meal. Ultimately, this survey serves as a valuable foundation for future research and
interventions aimed at enhancing patient education and understanding regarding the long-
term use of proton pump inhibitors.
2024-01-15T00:00:00Z