Literature Review on "Multifaceted Role of Phytoconstituents on Alzheimer's Disease: How Far Science Has To Be Progressed?"

Abstract

Amyloid-beta (Aβ), aggregation, neuro-inflammation and several other cellular processes alters these which causes of Alzheimer's disease (AD), a common neurodegenerative brain disease. The most typical kind of dementia, AD, continues to impact a large number of people worldwide. It's unclear what exactly caused the disease. There are currently no cures available that work to slow down or perhaps stop the development of AD. Many natural compounds are extracted from various sources and studied in both preliminary and clinical environments for neuroprotective properties in the prevention and treatment of AD. Moreover, the therapy and prevention of AD have shown promise for natural compounds and their derivatives. Natural bioactive substances actively modulate the pathogenic molecular pathways that lead to the development of AD. The focus of this review is on plant-based natural compounds and their derivatives that have shown neuroprotective properties and may show promise in the treatment and prevention of AD. The literature on using natural items as AD therapy agents is also summarized in this article. Most bioactive compounds for the therapeutics of AD have a number of drawbacks, including rapid metabolism, poor solubility, and impermeable blood–brain barrier, and limited bioavailability. Many methods use for nanotechnology and nano-carriers are possible. Keywords: Alzheimer’s disease; natural products; amyloid-beta; amyloid precursor