A Review of Tumor-Associated Macrophages and Neutrophils and Their Possible Interactions in the Tumor Microenvironment.

Abstract

Cancer is influenced by the tumor microenvironment (TME), which is characterized by inflammation and a variety of stromal components. Cancer cells encounter different types of stromal and immune cells throughout the disease process. The TME is a significant predictor of tumor behavior, contrary to the traditional oncological theory that describes cancer development as a multi-stage process affecting only cancer cells. The TME includes local stromal cells such as fibroblasts and macrophages, and far-flung recruited cells such as endothelial cells, immune cells, bone marrow-derived precursor cells, and circulating platelets. Among the myeloid populations in TAMs, MDSCs, TANs, and tumor-associated dendritic cells. We will focus on TAMs and TANs, both originating from TAMCs. Keywords: Tumor microenvironment, Inflammation, Stromal cells, Immune cells, Myeloid cells.