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Multifunctional Role of Natural Products for the Treatment of Parkinson's Disease

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dc.contributor.author Rahman, Md. Mominur
dc.contributor.author Wang, Xiaoyan
dc.contributor.author Islam, Md. Rezaul
dc.contributor.author Akash, Shopnil
dc.contributor.author Supti, Fatema Akter
dc.contributor.author Mitu, Mohona Islam
dc.contributor.author Harun-Or-Rashid, Md.
dc.contributor.author Aktar, Most. Nazmin
dc.contributor.author Kali, Most. Sumaiya Khatun
dc.contributor.author Jahan, Farhana Israt
dc.contributor.author Singla, Rajeev K.
dc.contributor.author Shen, Bairong
dc.contributor.author Rauf, Abdur
dc.contributor.author Sharma, Rohit
dc.date.accessioned 2023-07-15T10:03:23Z
dc.date.available 2023-07-15T10:03:23Z
dc.date.issued 22-10-16
dc.identifier.uri http://dspace.daffodilvarsity.edu.bd:8080/handle/123456789/10831
dc.description.abstract Natural substances originating from plants have long been used to treat neurodegenerative disorders (NDs). Parkinson’s disease (PD) is a ND. The deterioration and subsequent cognitive impairments of the midbrain nigral dopaminergic neurons distinguish by this characteristic. Various pathogenic mechanisms and critical components have been reported, despite the fact that the origin is unknown, such as protein aggregation, iron buildup, mitochondrial dysfunction, neuroinflammation and oxidative stress. Anti-Parkinson drugs like dopamine (DA) agonists, levodopa, carbidopa, monoamine oxidase type B inhibitors and anticholinergics are used to replace DA in the current treatment model. Surgery is advised in cases where drug therapy is ineffective. Unfortunately, the current conventional treatments for PD have a number of harmful side effects and are expensive. As a result, new therapeutic strategies that control the mechanisms that contribute to neuronal death and dysfunction must be addressed. Natural resources have long been a useful source of possible treatments. PD can be treated with a variety of natural therapies made from medicinal herbs, fruits, and vegetables. In addition to their well-known anti-oxidative and anti-inflammatory capabilities, these natural products also play inhibitory roles in iron buildup, protein misfolding, the maintenance of proteasomal breakdown, mitochondrial homeostasis, and other neuroprotective processes. The goal of this research is to systematically characterize the currently available medications for Parkinson’s and their therapeutic effects, which target diverse pathways. Overall, this analysis looks at the kinds of natural things that could be used in the future to treat PD in new ways or as supplements to existing treatments. We looked at the medicinal plants that can be used to treat PD. The use of natural remedies, especially those derived from plants, to treat PD has been on the rise. This article examines the fundamental characteristics of medicinal plants and the bioactive substances found in them that may be utilized to treat PD. en_US
dc.language.iso en_US en_US
dc.publisher Scopus en_US
dc.subject Therapeutic en_US
dc.subject Natural Products en_US
dc.subject Medicinal plants en_US
dc.title Multifunctional Role of Natural Products for the Treatment of Parkinson's Disease en_US
dc.title.alternative At a Glance en_US
dc.type Article en_US


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