Abstract:
Ethosomal systems are newer lipid vesicular carriers that have been around for 20 years, but over that period
they have grown significantly as a means of transdermal drug delivery. They have a sizable amount of ethanol in
them. These nanocarriers carry medicinal substances with various physicochemical qualities throughout the skin
and deep skin layers. Since they were created in 1996, ethosomes have undergone substantial investigation; new
substances have been added to their original composition, creating new varieties of ethosomal systems. These
innovative carriers, which can be added to gels, patches, and lotions, are prepared using several novel methods.
In addition to clinical trials, many in vivo models are employed to assess the effectiveness of dermal/transdermal
administration. This review focuses on different generation of ethosomes and their comparison with other
conventional liposomes.