Promising Roles of Lipid Nanoparticles Formulation of Naproxen

Abstract

For the purpose of delivering naproxen, a nonsteroidal anti-inflammatory medicine (NSAID), lipid nanoparticles (LNPs) are used in this systematic review of the literature. Although naproxen is frequently employed to treat pain, inflammation, and fever, its clinical application is constrained by its poor solubility and low bioavailability. To increase naproxen's bioavailability and therapeutic effectiveness, LNPs have been created as a viable drug delivery mechanism. The study cited a number of research that looked into the use of LNPs for naproxen delivery and showed that LNPs can enhance the pharmacokinetic and pharmacodynamic aspects of naproxen. The review also underlines the difficulties in developing and implementing LNPs on a large scale and explores possible solutions. LNPs are an optimistic method of delivering naproxen, Overall, LNPs represent a promising drug delivery system for naproxen, with the potential to improve its therapeutic efficacy and reduce its adverse effects. Keywords: lipid nanoparticle, naproxen, Ultra sonication, targeted drug delivery, bioavailability, pharmacokinetics, pharmacodynamics.