Abstract:
Despite the fact that various therapeutic compounds are being investigated, there is still a scarcity of effective
and reliable therapeutic regimens to treat COVID-19. Ever since the COVID-19 pandemic, a diversity of traditional herbal treatments has been investigated to cure infected people, either alone or in conjunction with
mainstream pharmaceuticals, with encouraging outcomes. In this article, we look at the latest research on the
usage of natural products to alleviate the severity of COVID-19. To determine the activity of the natural products,
act against SARS-CoV-2 to various targets like Mpro, ACE-II, papain-like, chymotrypsin-like proteases, and some
antiviral targets. The processes underlying this preventative or therapeutic action are also examined. We used
PubMed, Scopus, Google Scholar, and the WHO site to perform our review. The anti-SARS-CoV-2 impacts of
various herbal extracts and purified compounds may be mediated via direct prevention of viral replication or
entrance. Interestingly, certain items might avert SARS-CoV-2 from infecting human cells by blocking the ACE-2
protein or the serine protease TMPRRS2. Natural products have also been stated to suppress proteins intricate in
the virus life cycle, like papain-like and chymotrypsin-like proteases. To conclude, natural products can be used
alone or in combination as remedies or treatments for COVID-19. In addition, their compositions may provide
insight into the development of effective and reliable antiviral drugs.
