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Tacrine Derivatives in Neurological Disorders

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dc.contributor.author Mitra, Saikat
dc.contributor.author Muni, Maniza
dc.contributor.author Shawon, Nusrat Jahan
dc.contributor.author Das, Rajib
dc.contributor.author Emran, Talha Bin
dc.contributor.author Sharma, Rohit
dc.contributor.author Chandran, Deepak
dc.contributor.author Islam, Fahadul
dc.contributor.author Hossain, Md. Jamal
dc.contributor.author Safi, Sher Zaman
dc.contributor.author Sweilam, Sherouk Hussein
dc.date.accessioned 2024-03-20T05:11:13Z
dc.date.available 2024-03-20T05:11:13Z
dc.date.issued 2022-08-18
dc.identifier.uri http://dspace.daffodilvarsity.edu.bd:8080/handle/123456789/11735
dc.description.abstract Tacrine is a drug used in the treatment of Alzheimer’s disease as a cognitive enhancer and inhibitor of the enzyme acetylcholinesterase (AChE). However, its clinical application has been restricted due to its poor therapeutic efficacy and high prevalence of detrimental effects. An attempt was made to understand the molecular mechanisms that underlie tacrine and its analogues influence over neurotherapeutic activity by focusing on modulation of neurogenesis, neuroinflammation, endoplasmic reticulum stress, apoptosis, and regulatory role in gene and protein expression, energy metabolism, Ca2+ homeostasis modulation, and osmotic regulation. Regardless of this, analogues of tacrine are considered as a model inhibitor of cholinesterase in the therapy of Alzheimer’s disease. The variety both in structural make-up and biological functions of these substances is the main appeal for researchers’ interest in them. A new paradigm for treating neurological diseases is presented in this review, which includes treatment strategies for Alzheimer’s disease, as well as other neurological disorders like Parkinson’s disease and the synthesis and biological properties of newly identified versatile tacrine analogues and hybrids. We have also shown that these analogues may have therapeutic promise in the treatment of neurological diseases in a variety of experimental systems. en_US
dc.language.iso en_US en_US
dc.publisher Daffodil International University en_US
dc.subject Alzheimer’s disease en_US
dc.subject Treatment en_US
dc.subject Medicine en_US
dc.title Tacrine Derivatives in Neurological Disorders en_US
dc.title.alternative Focus on Molecular Mechanisms and Neurotherapeutic Potential en_US
dc.type Article en_US

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