Abstract:
Proton pump inhibitors (PPIs), also called gastric medicine, are among the most
frequently prescribed medications globally. Medications such as Esomeprazole,
Omeprazole, Pantoprazole, and others have nearly become ubiquitous in Bangladesh.
Although available in various forms on the market, capsules (pellets) are the most
prevalent.
Analyzing pharmaceuticals is laborious because only a limited number of
pharmaceutical companies produce them internally; the rest purchase granules that have
been filled into capsule shells and sold. Thus, only a few in-house methods exist to
facilitate the analytical process. The majority of them rely on pharmacopoeial methods
such as BP and USP. Although these techniques are widely used, they may only apply
to some pharmaceuticals. Therefore, this study is preoccupied with developing a novel
technique to facilitate the analysis of PPI pellets.
It is a finished product for a company that has only sold granules; it is a raw material
for a purchaser. The analytical technique can, therefore, be identical for both.
For an analyst to analyze these PPI granules, an effective method for both the primary
material and the final product must exist. This analysis uses High-Performance Liquid
Chromatography (HPLC), the most effective method for separating and identifying
mixtures of various components. In addition, distinct reagent and chromatographic
conditions are implemented, given that this is a novel methodology.
The ultimate findings exhibit encouraging results. This approach reduces both time and
analysis costs, albeit with minor drawbacks.
Esomeprazole, PPI, particle analysis, HPLC, and the development of analytical
methods are all keywords.
