Abstract:
Neuronal cell survival, proliferation, and neurogenesis are all
dependent on insulin-like growth factor-1/glucagon like pep-
tide-1 (IGF-1/GLP-1) signaling. In the last few decades, the
downregulation of IGF-1 and GLP-1 has been linked to pro-
blems in the nervous system and these two proteins have
become possible therapeutic targets for a number of neuro-
degenerative and neuropsychiatric disorders. Consequentially,
activation of the IGF-1/GLP-1 receptor may play a vital role in
neuronal protection. In their review, Bhalla et al. [1] put toge-
ther evidence about how IGF-1 and GLP-1 signaling target
activators could be used to treat neurological disorders. The
analogy of IGF-1 and GLP-1 cross the blood–brain barrier and
perform neuroprotective functions such as synaptic formation,
neuronal plasticity, protein synthesis, and autophagy.
