Identification of Molecular Biomarkers and Key Pathways Among Idiopathic Pulmonary Fibrosis (IPF), Chronic Obstructive Pulmonary Disease (COPD) and Lung Cancer

Abstract

Lung cancer (LC), idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD) are the most fatal disorders in the globe, generating frequent human issues. Having IPF and COPD are the risk factors of the LC, but the molecular mechanisms that underlie among IPF, COPD, and LC are not yet elucidated. In this study, we looked for shared molecular indicators and pathways that might explain how individuals with IPF, COPD, and LC are related to one another. GSE24206, GSE76925 and GSE18842 microarray datasets are utilized for IPF, COPD and LC samples. The preprocessing of datasets has done using R language, and then concordant differentially expressed genes (DEGs) are discovered. After that the protein-protein interactions (PPIs) are built using the similar DEGs, and the hub genes are determined using topological analysis. ETS1, MSH2, SORD, RORA and NEDD9 are the PPI network's top 5 hub genes. The pathways of KEGG demonstrated that the concordant DEGs are related to the colorectal cancer and pathways in cancer. Future work for this project will focus on miRNA, TF, and gene ontology (GO) analyses, as well as module analysis networks. Finally, based on the concordant DEGs, a number of potential medications have been suggested. © 2023 IEEE.