dc.description.abstract |
Wounds represent various significant health concerns for patients and also contribute major costs to healthcare systems.
Wound healing comprises of overlapped and various coordinated steps such as homeostasis, inflammation, proliferation, and
remodeling. In response to the failure of many strategies in delivering intended results including wound closure, fluid loss
control, and exhibiting properties such as durability, targeted delivery, accelerated action, along with histocompatibility,
numerous nanotechnological advances have been introduced. To understand the magnitude of wound therapy, this sys-
tematic and updated review discussing the effectiveness of nanoemulsions has been undertaken. This review portrays
mechanisms associated with wound healing, factors for delayed wound healing, and various technologies utilized to treat
wounds effectively. While many strategies are available, nanoemulsions have attracted the tremendous attention of scientists
globally for the research in wound therapy due to their long-term thermodynamic stability and bioavailability. Nanoemulsions
not only aid in tissue repair, but are also considered as an excellent delivery system for various synthetic and natural actives.
Nanotechnology provides several pivotal benefits in wound healing, including improved skin permeation, controlled release,
and stimulation of fibroblast cell proliferation. The significant role of nanoemulsions in improved wound healing along with their
preparation techniques has also been highlighted with special emphasis on mechanistic insights. This article illustrates recent
research advancements for the utilization of nanoemulsions in wound treatment. An adequate literature search has been
conducted using the keywords ‘Nanoemulsions in wound healing’, ‘Wound therapy and nanoemulsions’, ‘Herbal actives in
wound therapy’, ‘Natural oils and wounds treatment’ etc., from PubMed, Science Direct, and Google Scholar databases.
Referred and original publications in the English language accessed till April 2022 has been included, whereas nonEnglish
language papers, unpublished data, and nonoriginal papers were excluded from the study. |
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