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The Current Evidence for the Therapeutic Role of Curcumin in Alzheimer’s Disease

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dc.contributor.author Bland, Abigail R
dc.contributor.author Ashton, John C.
dc.contributor.author Kamal, Mohammad Amjad
dc.contributor.author Sahebkar, Amirhossein
dc.date.accessioned 2024-09-01T09:54:08Z
dc.date.available 2024-09-01T09:54:08Z
dc.date.issued 2023-03-07
dc.identifier.uri http://dspace.daffodilvarsity.edu.bd:8080/handle/123456789/13318
dc.description.abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, accounting for ap- proximately 60-80% of all dementia cases, with an estimated 24 million patients worldwide [1]. The disease affects cognitive function, resulting in memory, language, and behavioral deficits and an inability to perform basic daily activities [1]. Although the exact mechanism surrounding the development of AD is not well understood, one major hypothesis is that neuronal loss is sub- sequent to neuroinflammation, following deposition of amyloid-β (Aβ) plaques and the genera- tion of neurofibrillary tangles (which is a result of abnormal tau protein phosphorylation) [2]. Aβ plaques are created following the cleavage of amyloid precursor protein (APP) by β- and γ-secretases into insoluble Aβ peptides. The aggregates of Aβ have multiple neurotoxic mechanisms including binding to Ca2+ channels (which increases intracellular Ca 2+ levels and induces exci- totoxicity apoptosis), producing oxidative stress (via increasing levels of reactive oxygen species) and initiating the formation of neurofibrillary tangles (which produce neuronal death due to a communication disruption between neurons) [3]. Currently, the only approved drugs for the treatment of AD are used for symptomatic relief and do not prevent disease progression [4]. en_US
dc.language.iso en_US en_US
dc.publisher Bentham Science Publishers Ltd. en_US
dc.subject Alzheimer’s disease en_US
dc.subject Neurological disorders en_US
dc.title The Current Evidence for the Therapeutic Role of Curcumin in Alzheimer’s Disease en_US
dc.type Article en_US


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