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The Role of Non-coding RNAs in Alzheimer’s Disease: Pathogenesis, Novel Biomarkers, and Potential Therapeutic Targets

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dc.contributor.author Saleh, Othman
dc.contributor.author Albakri, Khaled
dc.contributor.author Altiti, Abdalrahmn
dc.contributor.author Abutair, Iser
dc.contributor.author Shalan, Suhaib
dc.contributor.author Mohd, Omar Bassam
dc.contributor.author Negida, Ahmed
dc.contributor.author Mushtaq, Gohar
dc.contributor.author Kamal, Mohammad A
dc.date.accessioned 2024-10-03T08:33:10Z
dc.date.available 2024-10-03T08:33:10Z
dc.date.issued 2023-06-13
dc.identifier.uri http://dspace.daffodilvarsity.edu.bd:8080/handle/123456789/13535
dc.description.abstract Long non-coding RNAs (IncRNAs) are regulatory RNA transcripts that have recently been associated with the onset of many neurodegenerative illnesses, including Alzheimer's disease (AD). Several IncRNAs have been found to be associated with AD pathophysiology, each with a distinct mechanism. In this review, we focused on the role of IncRNAs in the pathogenesis of AD and their potential as novel biomarkers and therapeutic targets. Searching for relevant articles was done using the PubMed and Cochrane library databases. Studies had to be published in full text in English in order to be considered. Some IncRNAs were found to be upregulated, while others were downregulated. Dysregulation of IncRNAs expression may contribute to AD pathogenesis. Their effects manifest as the synthesis of beta-amyloid (Aβ) plaques increases, thereby altering neuronal plasticity, inducing inflammation, and promoting apoptosis. Despite the need for more investigations, IncRNAs could potentially increase the sensitivity of early detection of AD. Until now, there has been no effective treatment for AD. Hence, InRNAs are promising molecules and may serve as potential therapeutic targets. Although several dysregulated AD-associated lncRNAs have been discovered, the functional characterization of most lncRNAs is still lacking. en_US
dc.language.iso en_US en_US
dc.publisher Bentham Science Publishers Ltd. en_US
dc.subject Alzheimer’s disease en_US
dc.subject Pathogenesis en_US
dc.subject Biomarkers en_US
dc.title The Role of Non-coding RNAs in Alzheimer’s Disease: Pathogenesis, Novel Biomarkers, and Potential Therapeutic Targets en_US
dc.type Article en_US


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