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Targeted Therapies of Curcumin Focus on Its Therapeutic Benefits in Cancers and Human Health: Molecular Signaling Pathway-based Approaches and Future Perspectives

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dc.contributor.author Islam, Md. Rezaul
dc.contributor.author Rauf, Abdur
dc.contributor.author Akash, Shopnil
dc.contributor.author Trisha, Sadiya Islam
dc.contributor.author Nasim, Akram Hossain
dc.contributor.author Akter, Muniya
dc.contributor.author Dhar, Puja Sutro
dc.contributor.author Ogaly, Hanan A.
dc.contributor.author Hemeg, Hassan A.
dc.contributor.author Wilairatana, Polrat
dc.contributor.author Thiruvengadam, Muthu
dc.date.accessioned 2024-10-12T04:11:01Z
dc.date.available 2024-10-12T04:11:01Z
dc.date.issued 2024-01-20
dc.identifier.uri http://dspace.daffodilvarsity.edu.bd:8080/handle/123456789/13556
dc.description.abstract The curry powder spices turmeric (Curcuma longa L.), which contains curcumin (diferuloylmethane), an orange-yellow chemical. Polyphenols are the most commonly used sources of curcumin. It combats oxidative stress and inflammation in diseases, such as hyperlipidemia, metabolic syndrome, arthritis, and depression. Most of these benefits are due to their anti-inflammatory and antioxidant properties. Curcumin consumption leads to decreased bioavailability, resulting in limited absorption, quick metabolism, and quick excretion, which hinders health improvement. Numerous factors can increase its bioavailability. Piperine enhances bioavailability when combined with curcumin in a complex. When combined with other enhancing agents, curcumin has a wide spectrum of health benefits. This review evaluates the therapeutic potential of curcumin with a specific emphasis on its approach based on molecular signaling pathways. This study investigated its influence on the progression of cancer, inflammation, and many health-related mechanisms, such as cell proliferation, apoptosis, and metastasis. Curcumin has a significant potential for the prevention and treatment of various diseases. Curcumin modulates several biochemical pathways and targets involved in cancer growth. Despite its limited tissue accumulation and bioavailability when administered orally, curcumin has proven useful. This review provides an in-depth analysis of curcumin's therapeutic applications, its molecular signaling pathway-based approach, and its potential for precision medicine in cancer and human health. en_US
dc.language.iso en_US en_US
dc.publisher Elsevier en_US
dc.subject Curry powder en_US
dc.subject Curry(Spice) powder en_US
dc.subject Molecular en_US
dc.subject Human health en_US
dc.title Targeted Therapies of Curcumin Focus on Its Therapeutic Benefits in Cancers and Human Health: Molecular Signaling Pathway-based Approaches and Future Perspectives en_US
dc.type Article en_US


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