Abstract:
Proton pump inhibitors (PPIs) are widely prescribed for acid-related disorders like gastroesophageal reflux disease (GERD) and peptic ulcers due to their effectiveness in reducing gastric acid secretion. However, their overuse has become a significant concern in clinical practice. Several factors contribute to the irrational use of PPIs, including inappropriate prescribing, overthe-counter availability, and increased patient demand for quick symptom relief. Physicians often prescribe PPIs without clear diagnostic indications or fail to discontinue therapy when it's no longer necessary, leading to prolonged and unnecessary use. Over-the-counter availability exacerbates this issue, allowing patients to self-medicate without proper medical guidance, unaware of the risks associated with long-term use, such as nutrient malabsorption, increased infection risk, and kidney complications. Patient demand also plays a role, as many individuals expect rapid relief from gastrointestinal symptoms, pressuring healthcare providers to continue or initiate PPI therapy unnecessarily. The consequences of this overuse are far-reaching, including adverse health outcomes and increased healthcare costs due to unnecessary prescriptions and the management of related complications. Addressing this issue requires a multi-pronged approach, emphasizing evidence-based prescribing practices, patient education about the risks of long-term PPI use, and regulatory interventions to limit over-the-counter availability or ensure proper usage. By promoting the judicious use of PPIs and encouraging regular reassessment of therapy, healthcare systems can reduce the risks associated with prolonged use, minimize unnecessary costs, and optimize patient outcomes while maintaining the therapeutic benefits of PPIs for those who genuinely need them
