Investigation of the Synbiotic Effect of the fruit peel of Musa ornata and Sesamum indicum with Yogurt and Its Link to Antihyperlipidemic, Antihyperglycemic, and Hepatoprotective Activity on Experimental Mice

Abstract

Hyperglycemia, cardiovascular disease, and hepatic dysfunction have become the most common chronic disorders in the present time. Conventional drugs have Some common side effects like abdominal discomfort, nausea, lightheadedness, or immune problems as well as hypotension and effect on hepatic functions. To eradicate those side effects to some extent as well as to increase the awareness of consumer about natural supplements, this in vivo experiment is performed to investigate the potential of ripe fruit peel of Musa ornata and Sesamum indicum and yogurt (sample) as a fiber source against Carlyle vegetarian capsules (standard) on Wister albino mice for 14 days (about 2 weeks) as an alternative to traditional sources. For investigation, the synbiotic source of Carlyle capsule (0.06 g/kg) and the fiber containing group [Peel 1.29 gm + Seed .75 gm +Yogurt] (Per 3 mice) were used throughout the total experiments. The SGPT level was within the normal range as compared to the control (40.33 ± 1.76 IU/L) where the value for the fiber combination was (34.07 ± 5.9 IU/L). Remarkably, the effect on OGTT level for the control group was noted at 7.65 mmol/L whereas the fiber combination group was 6.32 mmol/L. The fiber combination actively affects the lipid profiles by keeping them within a normal range. Among the lipid profiles for control groups, HDL was 49.14 ± 1.05 mg/dl and LDL was 54.11 ± 1.15 mg/dl in comparison to fiber source combination which was 35.08 ± 1.86 mg/dl, 43.90 ± 1.48 mg/dl sequentially. The HDL and LDL level in standard are 41 ± 5.70 mg/dl and 26.8 ± 3.70 mg/dl which indicates effect of fiber source in sample mice group. So, it is expected that the fiber mix assumes an extraordinary part in forestalling cardiovascular and hepatic problems. Further parameters of this area should be explored to expand the legitimacy of these assertions.