Abstract:
This comprehensive review delves into the therapeutic potential of natural flavanones in the context of lung and colorectal cancer treatment. Exploring diverse facets, we elucidate the biological significance of flavanones, showcasing their antioxidant and anti-inflammatory properties. Unraveling intricate mechanisms of action, our focus extends to angiogenesis inhibition, apoptosis induction, and molecular pathway modulation, unveiling flavanones as versatile agents in cancer therapy. Investigating dietary sources and intake, we navigate the incorporation of flavanones into prevention and treatment strategies through both natural sources and supplements. Preclinical studies highlight flavanones' impact on lung cancer, inhibiting growth, proliferation, and inflammation, offering promise for clinical translation. Similarly, flavanones exhibit anti-colorectal cancer properties, modulating key pathways, inducing apoptosis, and inhibiting metastasis, accentuating their potential in addressing a leading cause of cancerrelated mortality. Examining synergistic effects with chemotherapy, flavanones showcase the prospect of enhancing efficacy while minimizing side effects, laying the foundation for combination therapies. Biomarkers integrated into flavanone-based treatments emerge as a predictive tool, enabling personalized and targeted therapeutic strategies. Within the tumor microenvironment, flavanones demonstrate immunomodulatory effects, enhancing the anti-cancer immune response for sustained therapeutic benefits. This study serves as a roadmap for future investigations, fostering optimism for the integration of flavanones into precision medicine and personalized oncology interventions
