Abstract:
Mental health disorders, including cognitive impairment and anxiety disorders, pose significant challenges to global public health. Despite advancements in pharmacotherapy and psychotherapy, the quest for safe and efficacious treatment options remains ongoing. This comprehensive review explores the therapeutic potential of Centella asiatica (Gotu Kola) in mental health, synthesizing evidence from preclinical and clinical studies. Preclinical investigations have demonstrated Centella asiatica's ability to enhance cognitive function, mitigate anxiety and depression-like behaviors, and exert neuroprotective effects in various animal models. Clinical trials support these findings, showing significant improvements in cognitive function, anxiety, and depression symptoms among human participants. For instance, cognitive function improvement was observed in 75% of healthy adults following Centella asiatica supplementation, while reductions in anxiety symptoms were reported in 60% of patients receiving treatment. Moreover, approximately 70% of patients experienced a reduction in depressive symptoms with Centella asiatica supplementation. The herb's mechanisms of action involve modulation of neurotransmitter systems, neurogenesis promotion, and antioxidant properties. Additionally, Centella asiatica demonstrates stress management benefits and antiaging properties, further enhancing its therapeutic potential in mental health care. Integration of traditional knowledge with modern scientific methodologies facilitates a holistic understanding of Centella asiatica's therapeutic effects and cultural significance. Sustainable cultivation practices and formulation considerations are crucial for optimizing therapeutic outcomes and ensuring the availability of high-quality Centella asiatica. Overall, Centella asiatica emerges as a promising botanical remedy for enhancing cognitive function, alleviating anxiety and depression symptoms, and promoting mental well-being. Further research is warranted to elucidate its mechanisms of action, optimize treatment regimens, and explore its clinical applications in mental health care.
