Abstract:
In everyday life, we have to deal with stress, sadness, and depression which is very common in that time. Neurodisorders disrupt our personal and social life. The purpose of this research was to investigate the neuro-pharmacological characteristics of Malva parviflora leaves. CNS activity were investigated through hole cross, hole board and open field tests at varied extract dosages(50 & 125mg) per kg body weight, also aims to examine how Malva parviflora, a plant, may reduce stress levels by measuring blood glucose and serum cortisol levels. And To determine the impact of antidepressant medications on blood glucose and serum cortisol levels in experimental mice . In case of CNS depressant activity significantly reduction of frequent locomotor and exploratory activity was found in hole cross (P< 0.001) and open field test P < 0.05, P < 0.01, P < 0.001. Furthermore, both extracts also decreased the significant numbers (P < 0.001) of head dips by mice in hole-board test. On the other hand, Blood was collected by a cardiac puncture, and glucose and cortisol levels were measured using a spectrophotometer. The blood glucose level for herbal sample (chemical induction) were respectively 4.75 ±0.27 for high dose and low dose 3.76± 0.41 in compare to control were 4.83±0.88 mmol/L. It was 5.16±0.88 for standard groups. Secondly for Heat Induction The blood glucose level for herbal sample were respectively 4.85±0.37 for high dose and low dose 5.43± 0.04 comparing with control group which was 10.91±1.32 mmol/L. Where standard was 4.59±0.88 . For Serum cortisol level in Chemical Induced test 2.78± 0.10 & 1.51± 0.21 ug/dl for two plant extract and in standard group drug that was 1.32± 0.17 ug/dl & for control group it was 2.30± 0.11 and in heat induction, for control it was3.32± 0.54, for standard 1.47± 0.34 and lastly in terms of sample 200mg level was 2.97± 0.11 and for sample 400mg 2.12± 0.54 . According to this research, herbal plant have ability to reduce stress within a normal range, although further research is required to substantiate this claim
