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Thrombolytic, Analgesic and Antidiarrhoeal Activities of Methanol Extract of Bauhinia Acuminata Linn

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dc.contributor.author Shilpi, Rabeya Islam
dc.contributor.author Khan, Mohammad Firoz
dc.contributor.author Rahman, Md. Arifur
dc.contributor.author Sikder, Md. Al Amin
dc.contributor.author Rashid, Mohammad A.
dc.date.accessioned 2019-07-08T03:40:56Z
dc.date.available 2019-07-08T03:40:56Z
dc.date.issued 2014-07-01
dc.identifier.issn 1818–6238
dc.identifier.uri http://hdl.handle.net/123456789/2734
dc.description.abstract The present study was designed to evaluate the analgesic and antidiarrheal activities of a methanol extract and thrombolytic activity of methanol extract and its different partitionates obtained from the leaves of Bauhinia acuminata Linn. The analgesic activity was determined on mice model for its central and peripheral pharmacological actions using acetic acid-induced writhing and tail immersion tests, respectively and antidiarrheal effect was assessed by castor oil-induced diarrhea model at 200 and 400 mg/kg b.w. In in vitro thrombolytic study, the petroleum ether soluble materials of methanol extract revealed highest thrombolytic activity with clot lysis value of 46.66±0.67% as compared to 63.26±0.47% exhibited by the standard streptokinase. The extract significantly (P< 0.05) attenuated the acetic acid-induced writhing with the highest activity observed at 400 mg/kg b.w. (41.43%) comparable to that of the standard drug, diclofenac sodium (47.62%). A significant dose-dependent increase (P< 0.05) of latency period was also observed in the tail immersion method. During the castor oil-induced diarrheal assay, the extract showed significant (P<0.05) and dose dependant antidiarrheal effect. These findings indicate that sthe extract has potential thrombolytic, analgesic and antidiarrheal activity which support the folkloric claim and thus have great potential as a source of natural products. en_US
dc.language.iso en_US en_US
dc.publisher Daffodil International University en_US
dc.subject Bauhinia acuminata en_US
dc.subject Thrombolytic en_US
dc.subject Antidiarrheal en_US
dc.title Thrombolytic, Analgesic and Antidiarrhoeal Activities of Methanol Extract of Bauhinia Acuminata Linn en_US
dc.type Article en_US

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