Abstract:
Frusemide is a widely produced and marketed drug by many Pharmaceutical companies in Bangladesh. The performance evaluation (Namely, some physical parameters, potency, disintegration and dissolution profile), of Frusemide tablets from six different pharmaceutical companies was carried out in order to find out whether they really complied the required standards. As a part of evaluation of physical parameters, the size and shape, specially, thickness of representative samples of each pharmaceutical companies were evaluated and they were found to be uniform. The tablets from all the companies successfully passed the friability test as the % of friability of all of them were found to be way below one. Out of the tablets of six evaluated pharmaceutical companies, the potency of Frusemide tablets from five companies was found to be satisfactory and one was poor. The disintegration time of tablets from all the companies were found to be satisfactory. The minimum disintegration time was found to be 2.50 minute and the maximum disintegration was found to be 5 minutes. The dissolution profile of the representative sample was determined. The profiles for all the companies were satisfactory. The best profile was showed 90.42% at 45 minutes and 92.50% at 50 minutes.
