Abstract:
Metronidazole is a common antibiotic that is used to treat a wide variety of infections. It works by
stopping the growth of certain bacteria and parasites. The aim of this study is to prepare a formula
of metronidazole 200mg/ 400mg tablet and evaluate quality parameters of this products according
to the United States Pharmacopoeia (USP) and the British Pharmacopoeia (BP) methods. Although
the commercial price of this tablet is low, however, as the product is widely prescribed and
consumed by huge number of poor patients, this study may find a more economical formulation
that can obviously make an impression to patients. In this study the quality control parameters of
formulated tablets were evaluated by doing weight variation test, hardness test, thickness, friability
test, potency and dissolution by UV-spectroscopy following BP/USP criteria. The assay result and
dissolution rate studies showed quite similar with other brand’s tablet of metronidazole. By
considering the result of the quality parameters the quality and efficacy of the newly formulated
tablets were ensured and it may be marketed comparing metronidazole tablet.
