Abstract:
A series of new mixed anthranilic acid –
ethambutol complexes [Co(ETB)(Ant)Cl2] (1),
[Cd(ETB)(Ant)Cl2] (2), and [Cu(ETB)(Ant)Cl2] (3)
where ETB= Ethambutol and Ant= Anthranilic acid,
were synthesized by refluxing method and characterized
using spectroscopic techniques such as infrared and
ultraviolet/visible, elemental analysis, conductivity
measurement and magnetic susceptibility. The ligands
act as bidentate type coordinating to the central metal
ion through the oxygen of the hydroxyl group and
nitrogen of the amine group. Octahedral, square planar
and tetrahedral geometry has been assigned to the
Co(II), Cd(II) and Cu(II) complexes respectively.
Towards the in vitro biological potentials, the ligands
and the metal complexes were screened for
antibacterial, antioxidant and antitubercular activities.
The complexes were found to have an increased activity
compared to their free parent ligands. This research
work concluded that the mixed metal complexes of
anthranilic acid – ethambutol showed promising activity
against the selected organisms and as such exhibit
candidates for the treatment of ailments.
