Synthesis, Characterization and Biological Activity of Mixed hydroxyl

Abstract

A series of new mixed anthranilic acid – ethambutol complexes [Co(ETB)(Ant)Cl2] (1), [Cd(ETB)(Ant)Cl2] (2), and [Cu(ETB)(Ant)Cl2] (3) where ETB= Ethambutol and Ant= Anthranilic acid, were synthesized by refluxing method and characterized using spectroscopic techniques such as infrared and ultraviolet/visible, elemental analysis, conductivity measurement and magnetic susceptibility. The ligands act as bidentate type coordinating to the central metal ion through the oxygen of the hydroxyl group and nitrogen of the amine group. Octahedral, square planar and tetrahedral geometry has been assigned to the Co(II), Cd(II) and Cu(II) complexes respectively. Towards the in vitro biological potentials, the ligands and the metal complexes were screened for antibacterial, antioxidant and antitubercular activities. The complexes were found to have an increased activity compared to their free parent ligands. This research work concluded that the mixed metal complexes of anthranilic acid – ethambutol showed promising activity against the selected organisms and as such exhibit candidates for the treatment of ailments.