dc.contributor.author | Shaheen, Sharif Mohammad | |
dc.contributor.author | Rashid, Harun or | |
dc.contributor.author | W., Ferdous | |
dc.date.accessioned | 2022-01-16T05:16:52Z | |
dc.date.available | 2022-01-16T05:16:52Z | |
dc.date.issued | 2019-04-30 | |
dc.identifier.uri | http://dspace.daffodilvarsity.edu.bd:8080/handle/123456789/6757 | |
dc.description.abstract | In order to evaluate the activity of extracts on a castor oil-induced diarrhea model, three groups of rats (3 animals per group) were injected with ethanolic extracts of Gynura Procumbens (300 and 600mg / kg body weight) Orally in albino swiss mice. The other two groups received normal saline (3 mg / kg body weight) and loperamide (3 mg / kg body weight) as a positive control. The effect of the extract on intestinal passage and castor oil-induced intestinal fluid accumulation (intestinal reservoir) was evaluated. A significant and dose-dependent antidiarrheal activity was showed by the plant extract at oral doses of 300mg/kg and 600mg/kg body weight. The protective role of the extract at 600 mg / kg was comparable to that of loperamide (3 mg / kg) standard. No mortality and signs of visible weakness were observed in rats following administration of extracts at doses up to 1000 mg / kg. Our results showed that the extract of Gynura procumbens had significant antidiarrhoeic activity supporting its use in traditional herbal medicine practice. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Pharmacology online | en_US |
dc.subject | Antidiarrheal activity | en_US |
dc.subject | Castor oil | en_US |
dc.subject | Gynura procumbens | en_US |
dc.subject | Mortality | en_US |
dc.subject | Albino swiss mice etc. | en_US |
dc.title | Antidiarrheal Activity of a Mysterious Herb, Gynura Procumbense in Albino Swiss Mice | en_US |
dc.type | Article | en_US |