dc.contributor.author |
Satu, Md. Shahriare |
|
dc.contributor.author |
Howlader, Koushik Chandra |
|
dc.contributor.author |
Akhund, Tajim Md. Niamat Ullah |
|
dc.contributor.author |
Quinn, Julian M. W. |
|
dc.contributor.author |
Lio, Pietro |
|
dc.contributor.author |
Moni, Mohammad Ali |
|
dc.date.accessioned |
2022-01-23T06:53:46Z |
|
dc.date.available |
2022-01-23T06:53:46Z |
|
dc.date.issued |
2019-12-20 |
|
dc.identifier.uri |
http://dspace.daffodilvarsity.edu.bd:8080/handle/123456789/6876 |
|
dc.description.abstract |
Mitochondrial-dysfunction is linked to various neurological diseases. To understand these complications we developed a quantitative framework to explore how mitochondrial-dysfunction influences the progression of Alzheimer's, Parkin-son's, Huntington's, Amyotrophic Lateral Sclerosis and Cerebral Palsy. We sought insights from the gene profiles of mitochondrial and associated neurological disorders by constructing gene-disease networks. We also employed KEGG pathways and Gene Ontology to explore functional enrichment, and protein-protein interaction networks to identify the protein groups shared between these diseases. These identified potential biomarkers were verified using gold-benchmark databases. Our identified signature genes and pathways are useful to identify co-morbidity outcomes for the mitochondrial dysfunction. |
en_US |
dc.language.iso |
en_US |
en_US |
dc.publisher |
2019 22nd International Conference on Computer and Information Technology (ICCIT), IEEE |
en_US |
dc.subject |
Mitochondrial dysfunction |
en_US |
dc.subject |
Neurological disease |
en_US |
dc.subject |
Ontology |
en_US |
dc.subject |
Comorbidities |
en_US |
dc.subject |
Pathway |
en_US |
dc.title |
Comorbidity Effects of Mitochondrial Dysfunction to the Progression of Neurological Disorders |
en_US |
dc.title.alternative |
Insights from a Systems Biomedicine Perspective |
en_US |
dc.type |
Article |
en_US |