Abstract:
The advantages of microencapsule is to prevent the sensitive drug from contamination and to
ensure the controlled or sustained release of drug. It has a purpose to ensure the targeted drug
delivery to avoid the gastrointestinal fluid and enhance flow, compaction and core compression
characteristics. Chloramphenicol is an effective antibiotic for certain bacterial infections which
includes the usage of conjunctivitis as an eye treatment and meningitis, plague, cholera and
typhoid fever are treated by oral or injections into the vein. The aim of the study as
Chloramphenicol is X category drug for pregnant women then we can prevent the teratogenic
properties of this drug by micro encapsulant formulation. Ionotropic gelation method is one of
the safest and cost effective technique for microencapsulation. It is the easiest and effective
method for the Chloramphenicol micro encapsulant. Sustained release oral product namely
microbeads for Chloramphenicol prepared by ionotropic gelation technique using Sodium
alginate alone and combination with Hydroxypropyl methyl cellulose as release rate modifiers,
and investigated for in vitro drug release potential. While increase in the concentration of
sodium alginate and other polymer dispersions increased, the amount release of drug is
controlled due to time interval . In vitro drug release was dependent on the pH of the medium
and concentration of polymer dispersions. Among the six formulation batches F4, F5 and F6
were found to show optimum sustained effect 99.984%, 99.598% and 99.1972% respectively.
The mechanism of drug release from the microbeads was found to be followed super case-II
transport. Finally it has been determined that when the concentration of the polymers increase
it can ensure more controlled release of drug.
