In Vitro Quality Evaluation of Different Brands of Ebastine 10 Mg Tablets Commercially Available in Bangladesh

Abstract

The main purpose of this study was to evaluate and compare the quality control parameters of our different brands of Ebastine tablets available in Bangladesh. Different in vitro quality parameters including weight variation, friability, hardness, disintegration time, thickness, diameter, dissolution profile, and potency was assessed according to the compendial procedures. AccordingtoBPspecification, all tablets of each brand showed % weight variation within the range. All brands showed their friability within the USP designated limit of less than 0.5%. Within 30 minutes, tablets from all brands disintegrated completely which complies with BP and JP specifications andfourbrands could meet the first stage dissolution test. The study illustrates that all brands of Ebastinetablets showed acceptable results.