Abstract:
Chronic Kidney Disease (CKD), High Blood Pressure (HBP) and Thyroid Disorders (TD) are three
relational diseases, when human affected by one of them, increases the possibility affected those
people by other two diseases. Found large numbers of similarly biological and genetic features
among HBP, CKD, and TD. In this investigation, we will find out behind the reason for 3 diseases
are related to each other. Identify the common genes among HBP, CKD, and TD and finding the
most significant genes. First step of this investigation by reducing the number of reactive genes
intersection is obtained using RStudio. After completing this process, we have identified ten genes
that are shared by HBP, CKD, and TD. Based on the biological, biochemical, and genetic
relationships between common genes, this analysis identifies the most significant hub proteins.
We designed Protein-Protein Interactions network, Co-Expression network, Enrichment Analysis,
Topological properties analysis, Gene regulatory network, and Physical Interaction network based
on our understanding of biological, biochemical, and genetic relationships. This analysis allows
us to identify biological and genetic similarities between HBP, CKD, and TD. Finally, we've
arrived at our targeted hub proteins.
