Abstract:
A comparative transcriptomic analysis has performed to establish essential profiles of the gene
expression of SARS-CoV-2 linked to Cystic Fibrosis (CF). Transcriptomic studies have been
carried out in relation to SARS-CoV-2 since a number of people have been diagnosed with CF.
The recognition of differentially expressed genes demonstrated 8 concordant genes shared
between the SARS-CoV-2 and CF. Extensive gene ontology analysis and the discovery of
pathways enrichment demonstrated SARS-CoV-2 response to the CF. The gene ontological terms
and pathways enrichment mechanisms derived from this research may affect the production of
successful drugs, especially for the people with the following disorder. Identification of TFmiRNA association network reveals the interconnection between TF genes and miRNAs, which
may effective to reveals the other influenced disease that occurs for SARS-CoV-2 to CF. The
enrichment of pathways reveals SARS-CoV-2 associate CF mostly engaged with the type of
Innate Immune System, Toll-like receptor signaling pathway, Pantothenate and CoA biosynthesis,
Allograft rejection, Graft-versus-host disease, Intestinal immune network for IgA production,
Mineral absorption, Autoimmune thyroid disease, Legionellosis, Viral myocarditis, Inflammatory
bowel disease (IBD), etc. The drug compounds identification demonstrates the drug targets of
IMIQUIMOD and raloxifene are the most significant with the significant hub DEGs.
