Bioinformatics Methodology to Reveals the Common Biological Connection of Adult Onset Still’s Disease and Addison’s Disease

Abstract

In the current world, Adult Onset Still's Diseases and Addison's diseases are diagrammed as more human sicknesses to toss out regular infections for people. Ahead of time works, it is very much clear that Adult Onset Still's infection and Addison's sickness are affected by hereditary elements, and the standard engine technique sickness step by step. In this study we have collected the gene list of AOSD and AD from the DisGeNET database and then our target was to find out the common genes among them by implementing an intersecting program. Then I used those intersected data to construct and analyze the Protein -Protein Interaction Network (PPIN), Enrichment Analysis and others. After the end of this I have got the most common fundamental genes associated with these diseases, the interrelated interaction networks of this two disorder that will help me to better understand the common gene structure of them. From PPIN, 10 most responsible hub genes are obtained. In future by implementing further studies and analyzing those gene structures, it may be able to notify us to take precautionary steps to reduce the risk of those disease and analyzed Protein -drug interaction network.