Abstract:
Alzheimer's disease is a type of dementia that affects memory,thinking and behavior that means
it is a developing neurodegenerative disorder that slowly weaken memory and in time effect
the quality of life. There are many hypothesis concerning the pathophysiology of Alzheimer's
diseases. This review work aims to understand the role of reactive astrocytes in the
pathogenesis of Alzheimer's disease and its therapeutic mediate.It involves the causes and
diagnosis parts of AD as well. As per the hypothesis of AD accumulation of Amyloid beta
(Aβ), the main component of the plaques, is the causative agent of Alzheimer's pathology and
cell loss, vascular damage, and dementia take place as a result of this deposition. Roles of
reactive astrocytes in AD has been explained in this review work that are characterized by the
abnormal increase in the number of astrocytes due to infection, ischemia, strokes and
neurodegenerative disease. Finally altered glutamate homeostasis, cytokine and growth factor
sign, interleukin-6 and Suppressor of Cytokine Signaling 3, cyclooxygenase-2,
TGF- β1 and SMAD3 signaling have been explored here as therapeutic intervention. This
work reviews the scholarly articles that shows plausible relation between astrocytes role in
triggering CNS inflammation with remarkable inference for diverse CNS disorders
particularly Alzheimer’s disease.
