Abstract:
Amyloid-beta (A) AD aggregation, neuroinflammation, and a number of other processes are altered in cells as a result of Alzheimer's disease (AD), a prevalent neurodegenerative brain condition. The most common type of dementia, AD, continues to impact a large number of people worldwide. It's unclear what exactly caused the disease. As of right now, there are no effective drugs to slow down, stop, or cure AD. Numerous natural substances are extracted from various sources and studied in preclinical and clinical settings for their neuroprotective effects in the prevention and treatment of AD. Additionally, the treatment and prevention of AD have shown promise for natural compounds and their derivatives. Natural bioactive substances actively modulate the pathogenic molecular processes that lead to the development of AD.This review focuses on plant-based natural compounds and their derivatives that have shown neuroprotective properties and may show promise in the treatment and prevention of AD. The literature on using natural items as AD therapy agents is also summarized in this article. Most bioactive compounds have limitations in treating AD, including rapid metabolism, nonspecific targeting, low solubility, lack of BBB permeability, and limited bioavailability. We can employ nanotechnology and Nano carriers based on several strategies
