Hepatorenal Pharmacovigilance Study of Marketed Herbal Preparation of Carica papaya Leaves in Experimental Rat

Abstract

Herbal medications are natural remedies that have been used for hundreds of years because of their better patient tolerance & beneficial effects on health, however, safety issues still exist. Present study was conducted with the aim to find out the pharmacovigilance effects of the herbal preparation over two primary organs (liver & kidney) in experimental rat model. As sample, Carica papaya leaf extract and supplied marketed herbal drug & Peracetamol as toxicity inducing agent were used. Few parameters (CRP, ALT, and creatinine) and morphological alterations were observed after carrying out this treatment for 21 days. It was found that marketed herbal preparation have shown harmful effect over liver. CRP levels have been found to be elevated (0.60±0.01 mg/L), as well as ALT level (88±2.5 iU/L). However, the serum creatinine was within the normal range (0.41±0.02 mg/dl), concluding that there were no adverse effects observed on the kidneys. A morphological investigation shows that the liver and kidney have not undergone any detrimental or abnormal alterations. However, further research is required to fully comprehend how these medications affect our major organs. Key words: Herbal, Nutraceuticals, Papaya Leaf, Pharmacovigilance, CRP, ALT, Creatinine, Liver, Kidney