Phytochemical Screening and in Vitro Thrombolytic Potential of the Methanolic Extract of Combretum Indicum

Abstract

According to the results of the most recent study, the leaves of the plant known as C. indicum have the potential to be beneficial in the treatment of diabetes as well as the problems that are linked with the condition. These potential advantages might include the preservation of the pancreas via the regeneration of damaged beta islets as well as an improvement in the lipid profile. The thrombolytic processes are not significantly altered as a result of this factor. However, further study is required in order to comprehend the procedure and identify the compounds that are biologically active. This extract of C. indicum was carried out using a solvent containing methalonoic acid. In the presence of in-vitro thrombolytic activity, lysis of 68.81% of the clots was achieved by treating them with 100 ml of streptokinase (30,000 I.U.) and incubating the mixture at 37 degrees Celsius for 90 minutes. The rate of clot lysis was very low (3.44%) when the clots were treated with 100 microliters of sterile distilled water (a negative control). During an in-vitro thrombolytic activity test, the metabolic extracts of Combretum indicum exhibited a clot lysis rate of 6.57%. Using a statistical model that comprised a negative control (sterile distilled water), a positive control (Streptokinase), and Combretum, a calculation was made to determine the effective clot lysis percentage.