Abstract:
As a pre-requested requirement for importing any medicine to any country or in Bangladesh
point of view for any types of medicines export the company have to submit in-vivo
bioequivalence study report. However according to Shargel Waivers of in-vivo Bioequivalence
studies (Biowaivers), in some cases, in-vitro dissolution testing may be used in lieu of in-vivo
bioequivalence studies. The aim of the present study is to evaluate the bioequivalence quality of
different brands of Losartan potassium that are regularly exported to several foreign countries.
Three different brands of Losartan potassium of Bangladesh as well as one patented drug are
tested according to BP/USP specified procedure where USP apparatus II was used. The result
showed that, three brands of Losartan Potassium tablets meet the USP specification. All brands
tested, showed a good result for dissolution rate.
