Abstract:
Abstract
Pantoprazole is a widely produced and marketed drug by many Pharmaceutical
companies in Bangladesh. This study is done to compare the evaluation parameter
(friability, weight variation, assay, disintegration and dissolution) of enteric coated
Pantoprazole tablets. Different brands of Pantoprazole tablets of top, middle and lower
listed company were collected from retail pharmacy of Bangladesh Market for their
evaluation test. Specified method of USP is followed for their evaluation test. RSD value
of weight variation of different drugs is in the range of (0.78-1.65)%, maximum friability
of the tablets of all brands is 0.4%, maximum disintegration time in phosphate buffer is
17.42 minutes, Maximum average potency among the brands is 98.14 % and minimum
potency is 94.60%, among the brands the maximum drug release in 0.1N HCl is 6.06 ,
minimum dissolution in phosphate buffer after 45 minutes is 79.94% and the maximum is
88.03%. The result of friability, weight variation, and assay and disintegration tests of all
marketed products comply with pharmacopoeial limit except some parameter in case of
lower listed company. This study is done to view the scenario of the quality of different
brands of Pantoprazole tablets in Bangladesh market.
