Comparative Study of Different Brands of Linagliptin Tablet with Innovator drug

Abstract

Linagliptin is a dipeptidyl peptidase 4 (DPP-4) inhibitors developed by Boehringer Ingelheim,which can be used to treat diabetes mellitus type-II. This study is done to compare the parameters (weight variation, hardness, disintegration, dissolution and assay) of film coated Linagliptin tablets. Different brands of Linagliptin tablets were collected from retail pharmacy of Bangladesh market for their evaluation test and compare with innovator drug (Trajenta). As it is an INN (International Nonproprietary Names) drug, specified method from ICH Guideline is followed for their evaluation test. The results of weight variation (±2), hardness (3.8-5.3kg/cm2), disintegration time (1.47 to 3.85 minutes), dissolution (97-106% in 0.1N HCl within 45 minutes) and assay (95-105%) tests of all marketed products comply with the Innovator drug and also with the specification. This study is done to view the scenario of the quality of different brands of Linagliptin tablets in Bangladesh market and to compare with innovator drug.