Performance Evaluation of Losartan Potassium Tablets of five Different Pharmaceutical Companies in Bangladesh

Abstract

Losartan potassium belongs to a group of medicines known as angiotensin-II receptor antagonists. Losartan potassium is widely produced and marked drug by many Pharmaceutical companies in Bangladesh. The performance evaluation (Namely, some physical parameters, potency, and disintegration and dissolution profile) of Losartan potassium tablets from five different pharmaceutical companies was carried out in order to find out whether they really complied the required standards. As a part of evaluation of physical parameters, the size and shape, specially, thickness of representative samples of each pharmaceutical company was evaluated and they were found to be uniform the tablets from all the companies successfully passed the friability test. Out of the tablets of five evaluated pharmaceutical companies, the potency of Losartan potassium tablets from five companies was found to be satisfactory. The disintegration time of tablets from all the companies were found to be satisfactory. The dissolution profile of the representative sample was determined. The profiles for all the companies were satisfactory. The best profile was showed 90.52% at 30 minutes and 100% at 45.