Abstract:
A bioequivalence study for the selection
of the alternative and feasible mode of
administration of esomeprazole pellets suspended
in some common soft liquid foods has been done.
20 mg of four different brands esomeprazole
pellets suspended in yogurt, orange juice, apple
juice and milk were analyzed in the gastric
environment using dissolution tester and high
performance liquid chromatography. The release
of the esomeprazole active was found more the
90% using these liquid foods except milk. The
optimal release of the active was found in the
system of apple juice (97.06%). Administration of
the esomeprazole pellets suspending in apple
juice may be a practical alternative for patients
who cannot swallow an intact capsule.
