OPTIMIZATION OF THE BIOEQUIVALENCE STUDY OF ESOMEPRAZOLE CAPSULE CONTENTS AFTER IN VITRO      SUSPENSION IN SOFT FOODS USING HPLC

Alauddin, M.; Hossain, K. M. Z; Rahman, M. A.; Kabir, A. S. M. H; Khan, I. H

dc.contributor.author	Alauddin, M.
dc.contributor.author	Hossain, K. M. Z
dc.contributor.author	Rahman, M. A.
dc.contributor.author	Kabir, A. S. M. H
dc.contributor.author	Khan, I. H
dc.date.accessioned	2012-11-10T05:48:51Z
dc.date.accessioned	2019-05-28T09:49:49Z
dc.date.available	2012-11-10T05:48:51Z
dc.date.available	2019-05-28T09:49:49Z
dc.date.issued	2009
dc.identifier.uri	http://hdl.handle.net/20.500.11948/499
dc.description.abstract	A bioequivalence study for the selection of the alternative and feasible mode of administration of esomeprazole pellets suspended in some common soft liquid foods has been done. 20 mg of four different brands esomeprazole pellets suspended in yogurt, orange juice, apple juice and milk were analyzed in the gastric environment using dissolution tester and high performance liquid chromatography. The release of the esomeprazole active was found more the 90% using these liquid foods except milk. The optimal release of the active was found in the system of apple juice (97.06%). Administration of the esomeprazole pellets suspending in apple juice may be a practical alternative for patients who cannot swallow an intact capsule.	en_US
dc.language.iso	en	en_US
dc.publisher	Daffodil International University	en_US
dc.subject	Bioequivalence, Esomeprazole pellets, Soft foods, Gastric environment, Dissolution.	en_US
dc.title	OPTIMIZATION OF THE BIOEQUIVALENCE STUDY OF ESOMEPRAZOLE CAPSULE CONTENTS AFTER IN VITRO SUSPENSION IN SOFT FOODS USING HPLC	en_US
dc.type	Article	en_US