The DSpace digital repository system captures, stores, indexes, preserves, and distributes digital research material. http://localhost:8080 2026-10-17T15:26:04Z 2026-10-17T15:26:04Z Parvez, Anwar Rahman, Md Anisur Shimki, Afia Ibnath Biswas, Partha Hasan, Md Hasibul Imtiaz, Md Sultana, Arifa Islam, Saiful Faraque, Arafat Amin, Md Faisal Bristi, Mst Sonia Akter Islam, Muhammad Torequl http://192.168.40.123:8080/handle/123456789/18133 2026-10-15T09:21:28Z 2026-12-14T00:00:00Z

A Comprehensive Analysis of Natural Bioactive Molecules for the Treatment and Control of Glioblastoma Multiforme (GBM) Targeting Underlying Molecular Mechanism Parvez, Anwar; Rahman, Md Anisur; Shimki, Afia Ibnath; Biswas, Partha; Hasan, Md Hasibul; Imtiaz, Md; Sultana, Arifa; Islam, Saiful; Faraque, Arafat; Amin, Md Faisal; Bristi, Mst Sonia Akter; Islam, Muhammad Torequl Glioblastoma multiforme (GBM) is a highly aggressive brain tumor characterized by rapid cellular proliferation and invasion, making it difficult to achieve a complete cure. Despite therapies like surgery, radiotherapy, and chemotherapy, GBM results in poor survival rates, with a median survival of just 1 year. This has led to the need for more effective treatment options with fewer side effects. The study aims to explore the mechanisms behind GBM and highlight the potential of natural bioactive compounds, either alone or in combination with conventional therapies, to provide synergistic effects. Several small natural molecules, such as resveratrol, curcumin, rutin, and icariin, have shown promising anticancer and apoptotic properties in drug-resistant and p53-mutant GBM cell lines. These compounds enhance the antitumor effects of temozolomide (TMZ), targeting glioma stem cells, reducing oxidative stress, preventing cell proliferation, triggering apoptosis, and impeding oncogenic processes. Furthermore, combining these bioactive molecules with advanced drug delivery systems offers potential for improved drug targeting, bioavailability, and blood-brain barrier (BBB) penetration, while minimizing off-target effects. This study is clinically significant as it provides alternative therapeutic insights for patients with advanced GBM cancer, particularly in real-world settings or regions where access to EV plus pembrolizumab is limited due to cost, availability, or regulatory constraints. This multimodal therapeutic approach demonstrates promise as a safer and more effective way to treat glioblastoma. Articles

2026-12-14T00:00:00Z Taalab, Sherif A. Ismail, Ahmed M. Maadawy, W.M. El Abdelrahman, Kamal Khandaker, Mayeen Uddin http://192.168.40.123:8080/handle/123456789/18132 2026-10-15T09:21:08Z 2024-10-24T00:00:00Z

Natural radioactivity, mineralogy and hazard assessment of syenogranites (ornamental stones) using a statistical approach Taalab, Sherif A.; Ismail, Ahmed M.; Maadawy, W.M. El; Abdelrahman, Kamal; Khandaker, Mayeen Uddin The study focused on syenogranite and its altered variety, and specifically monitored the activities of 226Ra, 232Th, and 40K using NaI(Tl) gamma-ray spectroscopy. Syenogranites in the study area in Egypt were investigated to determine their potential use in industries such as ornamental stones and ceramics. The main outcrops in the study area consist of metasediments, metavolcanics, metagabbro, syn-to late-orogenic granites, and post-orogenic granites (syenogranites). There are also numerous dikes and veins of various shapes and compositions that have intruded and penetrated all the older rocks in the area. The mean activity (± standard deviation, SD) of these radioelements in the granites is 226Ra (63 ± 71 Bq kg−1), 232Th (76 ± 170 Bq kg−1), and 40K (1248 ± 532 Bq kg−1) were found to be greater than the world average. The radiological hazards are mostly attributed to the γ-rays emitted by granitic rocks. The granites studied in this study deviate from international standards mainly due to the presence of minerals containing radioelements such as zircon, allanite, monazite, sphene titanite, apatite, thorite, samarskite, fergusonite, xenotime, columbite, apatite and fluorite. As a result, granitic rocks are unsuitable for home building. Articale

2024-10-24T00:00:00Z Alshammari, Anoud Saud Rilwan, U. Alafer, Feras Kamali, Marwan F.S.H. AL Almutery, Aml Taher, Atef El- http://192.168.40.123:8080/handle/123456789/18131 2026-10-14T09:28:54Z 2026-06-30T00:00:00Z

A comparative analysis of radiation shielding character in engineered bricks blended with CaO, Al2O3, and Fe2O3 additives: thermal stability and Phy-X simulation insights into attenuation characteristics Alshammari, Anoud Saud; Rilwan, U.; Alafer, Feras; Kamali, Marwan F.S.H. AL; Almutery, Aml; Taher, Atef El- This study employed Phy-X software to investigate the radiation protection efficacy of different bricks fabricated from a mixture of clay, CaO (calcium oxide), Al2O3 (aluminum oxide), and Fe2O3 (iron oxide). As the oxide additives substituted clay, an increased in the density of the fabricated samples was noticed, with CL5Fe showcasing the superior value of 2.40 g/cm3. An improved linear attenuation coefficient (LAC) was also noticed, with CL5Fe demonstrating the greatest LAC value of 0.154 cm−1 at 0.6 MeV, which could be associated to its superior density due to presence of Fe2O3. The 0.6 MeV energy was chosen as a representative 137Cs value within the Compton-dominant region. Shielding performance was further evaluated from 0.0459 to 1.46 MeV, covering photoelectric-to-Compton-dominated interactions. CL5Fe also outsmarted other samples in terms of thermal stability and structural integrity, making it the best choice for gamma radiation protection. Future studies should evaluate shielding performance across 1.47–15 MeV to assess material suitability for medical imaging, radiotherapy, and nuclear radiation environments. Articles

2026-06-30T00:00:00Z Bhuiyan, Md. Younus Ayon, Shahriar Siddique Hossain, Md. Ebrahim Miah, Md. Saef Ullah Sarower, Afjal H. Bappee, Fateha khanam http://192.168.40.123:8080/handle/123456789/18130 2026-10-14T09:28:48Z 2026-04-01T00:00:00Z

: A clinical dataset on type-2 diabetes including demographic, anthropometric, and biochemical parameters from Bangladesh Bhuiyan, Md. Younus; Ayon, Shahriar Siddique; Hossain, Md. Ebrahim; Miah, Md. Saef Ullah; Sarower, Afjal H.; Bappee, Fateha khanam Type-2 diabetes is a major public health concern in Bangladesh, and this dataset provides 1065 curated patient records with demographic, anthropometric, and clinical variables relevant to its assessment. The data were collected during routine clinical visits and recorded by trained staff, with checks to ensure accuracy and completeness. It includes basic details like age, pregnancy count, body mass index, and skin-fold thickness; vital signs such as blood pressure; lab results related to blood sugar (fasting glucose and insulin); the Diabetes Pedigree Function; and a simple yes/no label for Type-2 diabetes. A few values are missing for diastolic blood pressure and skin-fold thickness, so users should handle these carefully. Since the data are cross-sectional and come from patients seeking care, there are more diabetic cases (840) than non-diabetic cases (225). The dataset is intended for reuse in method development (for example, machine-learning classifier training, feature-selection benchmarking, and oversampling/imputation research), for context-specific epidemiologic description and model validation in South Asian clinical settings, and as a teaching resource for reproducible biomedical-data workflows. Articles

2026-04-01T00:00:00Z